Please forgive the ‘rough draft’ nature of this first post - hopefully it inspires some of you who are more hesitant to post something unpolished to just share your unpolished ideas so we can all polish them together! 
How to ‘max out the stats’ and grow the ‘best’ lettuce
Start by reading this post about what Cornell has by doing it for 20+ years: Cornell Lettuce Research Data
What not to do (Tipburn) - read the last lines in blue
Screenshot above is from this paper on tipburn: Causes of the tipburn disorder in leaves of vegetables - ScienceDirect
It’s already cited in that paper but just because she’s such a rockstar, I have to call out this 4-pager on Tipburn (print/share this with students - it’s super understandable!) created by Dr. Cheri Kubota, who now runs the CEA program at University of Ohio. https://e-gro.org/pdf/E810.pdf
Pretty technical but very concise summary of tipburn causes by UC Davis: https://ipm.ucanr.edu/agriculture/lettuce/tipburn/#gsc.tab=0